The onset of acute disease typically is insidious. Infants, children aged <5 years, and immunosuppressed adults with newly acquired HBV infection typically are asymptomatic, whereas 30%--50% of children aged > 5 years and adults have initial clinical signs or symptoms ( 14 ). When present, clinical symptoms and signs can include anorexia, malaise, nausea, vomiting, abdominal pain, and jaundice. Extrahepatic manifestations of disease (., skin rashes, arthralgias, and arthritis) also can occur ( 15 ). The fatality rate among persons with reported cases of acute hepatitis B is %--%, with the highest rates in adults aged >60 years; however, because a substantial number of infections are asymptomatic and therefore are not reported, the overall fatality rate among all persons with HBV infection likely is lower ( 16 ).
Qasim Aziz, MD, FRCP: GI Complication ins hEDS and HSD
Lara Bloom: The 2017 EDS Classification—The International Work of The Ehlers-Danlos Society
Prof. Antonin Bulbena: Handling Subjective and Emotional Dimensions in EDS
Marco Castori: Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders
Anne Maitland, MD, PhD: Having Signs and Symptoms of “None of the Above”? Think MCAS!
Dr. Jane Simmonds, MCSP, SFHEA: Physiotherapy Management of Hypermobility Spectrum Disorders and Hypermobile Ehlers-Danlos Syndrome Within the Context of the Multidisciplinary Team
We were very excited to bring together leading world experts to discuss Ehlers-Danlos syndromes and related disorders, including the newly-described hypermobility spectrum disorders. This was our first European conference. The local organizing committee of Henk Klooster, Debbie Hellenbrand, and Daniel Keszthelyi wass supported by The Ehlers-Danlos Society and Congress Cares .