Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years, mean years) male depressed outpatients. During 6 weeks of mesterolone treatment, there was a significant improvement of depressive symptomatology. However, since an improvement was also established during the placebo treatment, no statistically appreciable difference in the therapeutic effects of mesterolone was established compared to placebo. Mesterolone treatment significantly decreased both plasma testosterone and protein bound testosterone levels. Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels. The degree of improvement weakly correlated to the decrease of testosterone levels during mesterolone treatment.
Different testosterone esters are often blended into one injectable preparation. In some cases up to seven esters are used, but the most popular formulation is that of Sustanon 250 where four esters are mixed together. This is done to take advantage of the faster acting esters while still only requiring weekly or bi-weekly injections. It is often believed to be a superior form of testosterone, but in reality it’s nothing more than just testosterone. One drawback of testosterone blends are that they incorporate esters with long carbon chains and those chains occupy allot of molecular weight, so the actual dosage of hormone is less than one would obtain from shorter esters like propionate. Testosterone blends are most useful during bulking phases where frequent injections are not possible.
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